| Date | Location | Result | |
| May 28, 2010  | Houston, Texas   | Southern Miss 10, Houston 6  | Box score |
| May 27, 2010  | Houston, Texas   | Rice 24, Houston 3  | Box score |
| May 26, 2010  | Houston, Texas   | Houston 11, Marshall 7  | Box score |
| May 22, 2010  | Greenville, N.C.   | East Carolina 8, Houston 6  | Box score |
| May 21, 2010  | Greenville, N.C.   | Houston 7, East Carolina 6  | Box score |
| May 20, 2010  | Greenville, N.C.   | Houston 8, East Carolina 6  | Box score |
| May 18, 2010  | Houston, Texas   | Rice 15, Houston 5  | Box score |
| May 16, 2010  | Houston, Texas   | Houston 10, Marshall 1  | Box score |
| May 15, 2010  | Houston, Texas   | Marshall 5, Houston 3  | Box score |
| May 15, 2010  | Houston, Texas   | Houston 11, Marshall 6  | Box score |
| May 11, 2010  | Houston, Texas   | Texas A&M 12, Houston 3  | Box score |
| May 09, 2010  | Houston, Texas   | Tulane 8, Houston 6  | Box score |
| May 08, 2010  | Houston, Texas   | Tulane 15, Houston 2  | Box score |
| May 07, 2010  | Houston, Texas   | Houston 9, Tulane 7  | Box score |
| May 01, 2010  | Birmingham, Ala.   | Houston 7, UAB 4  | Box score |
| May 01, 2010  | Birmingham, Ala.   | Houston 16, UAB 11  | Box score |
| Apr 30, 2010  | Birmingham, Ala.   | UAB 11, Houston 6  | Box score |
| Apr 28, 2010  | Houston, Texas   | Houston 8, Lamar 7  | Box score |
| Apr 27, 2010  | Huntsville, Texas   | Sam Houston State 5, Houston 3  | Box score |
| Apr 25, 2010  | Hattiesburg, Miss.   | Southern Miss 8, Houston 5  | Box score |
| Apr 24, 2010  | Hattiesburg, Miss.   | Southern Miss 13, Houston 4  | Box score |
| Apr 23, 2010  | Hattiesburg, Miss.   | Southern Miss 10, Houston 9  | Box score |
| Apr 21, 2010  | Beaumont, Texas   | Lamar 7, Houston 6  | Box score |
| Apr 18, 2010  | Houston, Texas   | Houston 8, Memphis 6  | Box score |
| Apr 17, 2010  | Houston, Texas   | Memphis 8, Houston 2  | Box score |
| Apr 16, 2010  | Houston, Texas   | Houston 10, Memphis 7  | Box score |
| Apr 13, 2010  | San Antonio, Texas   | Houston 14, UTSA 8  | Box score |
| Apr 11, 2010  | Houston, Texas   | TCU 12, Houston 2  | Box score |
| Apr 10, 2010  | Houston, Texas   | TCU 6, Houston 1  | Box score |
| Apr 09, 2010  | Houston, Texas   | TCU 15, Houston 1  | Box score |
| Apr 06, 2010  | Houston, Texas   | Houston 4, Sam Houston State 2  | Box score |
| Apr 03, 2010  | Houston, Texas   | Rice 8, Houston 7  | Box score |
| Apr 02, 2010  | Houston, Texas   | Rice 11, Houston 2  | Box score |
| Apr 01, 2010  | Houston, Texas   | Rice 6, Houston 0  | Box score |
| Mar 30, 2010  | Houston, Texas   | UTSA 6, Houston 5  | Box score |
| Mar 28, 2010  | Houston, Texas   | Houston 20, UCF 3  | Box score |
| Mar 27, 2010  | Houston, Texas   | Houston 7, UCF 3  | Box score |
| Mar 26, 2010  | Houston, Texas   | UCF 7, Houston 4  | Box score |
| Mar 23, 2010  | Nacogdoches, Texas   | Houston 10, Stephen F. Austin 3  | Box score |
| Mar 21, 2010  | Tempe, Ariz.   | Arizona State 6, Houston 5  | Box score |
| Mar 20, 2010  | Tempe, Ariz.   | Arizona State 6, Houston 0  | Box score |
| Mar 19, 2010  | Tempe, Ariz.   | Arizona State 10, Houston 1  | Box score |
| Mar 17, 2010  | Berkeley, Calif.   | Houston 12, California 9  | Box score |
| Mar 16, 2010  | San Francisco, CA   | San Francisco 3, Houston 2  | Box score |
| Mar 14, 2010  | San Luis Obispo, CA   | Houston 5, Cal Poly 3  | Box score |
| Mar 13, 2010  | San Luis Obispo, CA   | Houston 6, Cal Poly 2  | Box score |
| Mar 12, 2010  | San Luis Obispo, CA   | Houston 13, Cal Poly 8  | Box score |
| Mar 07, 2010  | Houston, Texas   | Houston 15, Texas Tech 8  | Box score |
| Mar 06, 2010  | Houston, Texas   | Houston 1, Texas 0  | Box score |
| Mar 05, 2010  | Houston, Texas   | Houston 3, Missouri 0  | Box score |
| Mar 02, 2010  | Houston, Texas   | Rice 8, Houston 2  | Box score |
| Feb 28, 2010  | Houston, Texas   | Santa Clara 8, Houston 7  | Box score |
| Feb 27, 2010  | Houston, Texas   | Houston 3, Santa Clara 2  | Box score |
| Feb 26, 2010  | Houston, Texas   | Houston 17, Santa Clara 9  | Box score |
| Feb 21, 2010  | Houston, Texas   | Texas State 9, Houston 7  | Box score |
| Feb 20, 2010  | Houston, Texas   | Texas State 6, Houston 3  | Box score |
| Feb 19, 2010  | Houston, Texas   | Texas State 6, Houston 0  | Box score |
